Korean J Otorhinolaryngol-Head Neck Surg.  2015 Feb;58(2):147-152. 10.3342/kjorl-hns.2015.58.2.147.

A Case of Low Grade Osteosarcoma Developing in the Middle Skull Base after Radiotherapy of Adenoid Cystic Carcinoma in the Posterior Nasal Cavity

Affiliations
  • 1Department of Otorhinolaryngology-Head & Neck Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea. rohhj@pusan.ac.kr
  • 2Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Abstract

Adenoid cystic carcinoma arises rarely in the nasal cavity and paranasal sinus. Treatment strategy showing the best survival rate includes surgical excision and adjuvant radiotherapy. There were a few case reports of radiation-induced osteosarcoma from adenoid cystic carcinoma overseas but not in Korea. We experienced a case of radiation-induced low-grade osteosarcoma in the middle skull base including sphenoid bone, which had arisen after 10 years of radiotherapy of adenoid cystic carcinoma. Authors present this case with serial imaging findings and literature review.

Keyword

Adenoid cystic carcinoma; Nasal cavity; Osteosarcoma; Radiation; Radiation-induced neoplasms
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