J Korean Diabetes Assoc.  1999 Aug;23(4):552-561.

Relationship between Plasminogen Activator Inhibitor-1 (PAI-1), Lipoprotein(a) and Diabetic Retinopathy in Type 2 Diabetes Mellitus

• Choi SY
• Kim EY
• Kim KW
• Jung YY
• Ho J
• Ku YH
• Lee HK
• Kim MK

Abstract

BACKGROUND: Diabetic retinopathy is a major cause of visual loss today, especially in diabetic patients having disturbances in hemostasis. Plasma plasminogen activator inhibitor-1 (PAI-1) and lipoprotein (a) may be involved in the pathogenesis of diabetic retinopathy of type 2 diabetes mellitus. This study was undertaken to determine whether plasma PAI-1 and Lp(a) levels are increased in type 2 diabetic patients with retinopathy, and to identify factors influencing PAI-1 and Lp(a) levels.
METHODS
A total of 177 type 2 diabetic subjects were classified by the presence or absence of retinopathy, 92 and 85, respectively, and fasting blood samples were taken for assay of PAI-1, Lp(a), creatinine clearance, serum lipid profiles and C-peptide levels.
RESULTS
Subjects with retinopathy showed higher levels of PAI-1 (p<0.05), Lp(a) (p<0.01), total cholesterol (p<0.01), triglyceride (p<0.01) and longer disease duration than those without retinopathy. In multiple regression analysis, PAI-1 levels were significantly correlated with high density lipoprotein (HDL) cholesterol, while Lp(a) levels were correlated with body mass index, total cholesterol and low density lipoprotein (LDL) cholesterol.
CONCLUSION
These results suggest that elevated PAI-1and Lp(a) are associated with the presence of diabetic retinopathy.

Keyword

Key Words; Type 2 diabetes mellitus; Plasminogen activator inhibitor-l; Lipoprotein(a)

MeSH Terms

Body Mass Index
C-Peptide
Cholesterol
Creatinine
Diabetes Mellitus, Type 2*
Diabetic Retinopathy*
Fasting
Hemostasis
Humans
Lipoprotein(a)*
Lipoproteins
Plasma
Plasminogen Activator Inhibitor 1
Plasminogen Activators*
Plasminogen*
Triglycerides
C-Peptide
Cholesterol
Creatinine
Lipoprotein(a)
Lipoproteins
Plasminogen
Plasminogen Activator Inhibitor 1
Plasminogen Activators