J Cardiovasc Ultrasound.  2010 Sep;18(3):86-90. 10.4250/jcu.2010.18.3.86.

Relation of Anemia to Echocardiographically Estimated Left Ventricular Filling Pressure in Hypertensive Patients Over 50 Year-Old

• Kim YR
• Pyun WB
• Shin GJ

• KMID: 2177305
• DOI: http://doi.org/10.4250/jcu.2010.18.3.86

Abstract

BACKGROUND
Anemia is associated with worse long term outcomes in heart failure. However, there is little evidence on the effect of low hemoglobin level to the left ventricular (LV) structure and diastolic function in hypertensive patients. This study assessed the relationship of hemoglobin level to LV filling pressure in elderly hypertensive patients.
METHODS
From January 2005 to January 2009, 200 newly diagnosed hypertensive patients over 50 years old (mean age 60 +/- 6 years, 116 women) were analyzed. The clinical parameters and comprehensive echocardiographic data were obtained. The patients with and without anemia were compared.
RESULTS
There were significant differences between the anemic and non-anemic groups in the LV mass index (115.27 +/- 34.95 vs. 103.75 +/- 28.21 g/m2), left atrial (LA) volume index (29.31 +/- 10.74 vs. 24.99 +/- 7.43 mL/m2), and E/E' (11.92 +/- 4.34 vs. 9.37 +/- 2.51). Chronic renal failure was more prevalent in anemic group. On multivariate logistic analysis, anemia was significantly correlated with high LV filling pressure, reflected by E/E', even after controlling for LV mass index and LA volume index. Furthermore, E/E' was significantly correlated with the hemoglobin level (R2 = 0.093, p < 0.001).
CONCLUSION
In newly-diagnosed hypertensive patients over 50 years old, the presence of anemia was significantly associated with elevated LV filling pressure and LV structural changes. And the hemoglobin level was negatively correlated with noninvasively estimated LV filling pressure.

Keyword

Anemia; Hypertension; Left ventricular filling pressure

MeSH Terms

Aged
Anemia
Heart Failure
Hemoglobins
Humans
Hypertension
Kidney Failure, Chronic
Hemoglobins

Figure

• 

  Fig. 1 Relation of Hemoglobin levels with corresponding E/E' values, reflecting LV filling pressure, in hypertensive patients over 50 year-old. E/E': the ratio of early transmitral inflow to septal diastolic velocity of the mitral annulus.

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