J Korean Cancer Assoc.  2000 Jun;32(3):612-618.

Efficacy of Combination Chemotherapy with Vinorelbine, Ifosfamide, and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer

• Chang HM
• Lee JA
• Ahn JS
• Woo IS
• Park YI
• Son JW
• Lee SJ
• Kim DK
• Mo EK
• Park MJ
• Lee MG
• Hyun IG
• Jung KS
• Park YS

Abstract

PURPOSE: To evaluate the efficacy and toxicity of combination chemotherapy with vinorelbine, ifosfamide, and cisplatin in patients with advanced non-small cell lung cancer.
MATERIALS AND METHODS
Patients with unresectable, pathologically proven non-small cell lung cancer who had no prior chemotherapy were eligible. Patients received vinorelbine (25 mg/m2, iv., D1 & 8), ifosfamide (1.5 g/m2, iv., D1-3 with mesna), and cisplatin (60 mg/m2, iv., D1). The treatment was repeated every 3 weeks.
RESULTS
Between degrees Ctober, 1997 and June, 1999, 26 patients were enrolled. Median age was 61. 1 patient had stage IIIA, 13 had stage IIIB, and 12 had stage IV. Patients with adendegrees Carcinoma were 15, squamous cell carcinoma were 11. Of 22 evaluable patients, objective responses were observed in 9 patients (response rate: 40.9%, CR: 1 (4.5%), PR 8 (36.4%)). Median duration of response was 48 weeks. Median overall survival was 52 weeks. Grade 3-4 leukopenia was observed in 10.2% of the 88 courses. There was 1 death related to febrile neutropenia. Non- hematologic toxicities were mild.
CONCLUSION
We concluded that combination chemotherapy with vinorelbine, ifosfamide, and cisplatin was effective and tolerable in patients with advanced non-small cell lung cancer, and phase III randomized trial is needed to compare this regimen to other cisplatin-based regimens.

Keyword

Non-small cell lung cancer; Vinorelbine; Ifosfamide; Cisplatin; Chemotherapy

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
Carcinoma, Squamous Cell
Cisplatin*
Drug Therapy
Drug Therapy, Combination*
Febrile Neutropenia
Humans
Ifosfamide*
Leukopenia
Cisplatin
Ifosfamide