Chonnam Med J.  1999 Dec;35(4):467-474.

Factors Influencing the Relapse in Graves' Disease Treated with Antithyroid Drug

• Ruy SS
• Park JS
• Kang SJ
• Hong GY
• Woo YA
• Kim SH
• Im JG
• Rhee JA

Abstract

OBJECTIVES
To evaluate predicting factors related to the relapse of Graves' disease patients. treated with antithyroid drug.
METHODS
This study enrolled 134 patients who recieved antithyroid drug treatment for Graves' disease at the Department of Internal Medicine of Kwangju Christian Hospital from January 1994 to December 1994. The patients were treated with antithyroid drug therapy for 12 months and then followed up the recurrence of disease for 24 months. The patients were divided into two groups as 79 patients of relapsing group and 55 patients of remission group. Author estimated the serum concentration of T3, T4, thyroid stimulating hormone(TSH), thyrotropin binding inhibitor immunoglobulin (TBII) at the time of finishing, 1 month after and 3 months after of antithyroid drug therapy.
RESULTS
As a result of study, the relapsed group had positive value of serum TBII activity (p<0.01), lager pre-treatment size of goiter (p<0.05), lower value of log TSH(p<0.05), and male population. By the multivariate logistic regression analysis, serum TBII activity and pre-treatment size of Goiter were showed 4.0 (1.5-10.5), 2.7 (1.2-6.0) in odds ratio respectively.
CONCLUSIONS
This study suggests that serum TBII activity and pre-treatment goiter size can be predicting factors relating relapse of Graves' disease.

Keyword

Predicting factor; Relapsing; Antithyroid drug therapy; Graves' disease

MeSH Terms

Drug Therapy
Goiter
Graves Disease*
Gwangju
Humans
Immunoglobulins
Internal Medicine
Logistic Models
Male
Odds Ratio
Recurrence*
Thyroid Gland
Thyrotropin
Immunoglobulins
Thyrotropin