Korean J Med.  2008 Sep;75(3):362-366.

Agranulocytosis due to secondary exposure to antithyroid drugs in a relapsed Graves' disease patient

Affiliations
  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. mychung@chonnam.ac.kr

Abstract

Antithyroid drugs are the most common treatment modality for Graves' disease and are used for the treatment of relapsed Graves' disease in Korea. Agranulocytosis is a rare and severe complication of antithyroid drug therapy, and most cases occur within 3 month after drug treatment. Agranulocytosis can develop in patients who have relapsed Graves' disease and undergo a second course of antithyroid drugs with a prior uneventful course of drug therapy. We report a case of antithyroid drug-induced agranulocytosis in a relapsed Graves' disease patient who had undergone prior uneventful antithyroid drug therapy. We also present a review of the relevant literature.

Keyword

Graves' Disease; Recurrence; Antithyroid agents; Agranulocytosis

MeSH Terms

Agranulocytosis
Antithyroid Agents
Graves Disease
Humans
Korea
Recurrence
Antithyroid Agents
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