Ewha Med J.  2014 Sep;37(2):98-104. 10.12771/emj.2014.37.2.98.

Stomach and Colon Metastasis from Breast Cancer

• Yu HA
• Kim EY
• Seo MJ
• Chung E
• Cho MJ
• Oh HJ
• Jang JH
• Park JC
• Lee JU
• Park SY

• KMID: 2171290
• DOI: http://doi.org/10.12771/emj.2014.37.2.98

Abstract

Gastric metastasis from breast cancer is rare and only six cases have been reported in Korea. Colon metastasis is more rare than gastric metastasis. We report a 63-year-old woman with gastric and colon metastases of invasive lobular carcinoma of breast. She was diagnosed as right breast cancer, received right modified radical mastectomy 10 years ago and has been treated with chemotherapy and hormone therapy. Investigating for melena and a small caliber of stool, we found gastric and colon metastases. The diagnosis of metastatic breast cancer was made through gross pathologic and immunohistochemistry staining. We report a case with gastric and colon metastases from breast cancer and a review of the associated six case reports in Korea.

Keyword

Breast neoplasms; metastasis; stomach; colon

MeSH Terms

Breast
Breast Neoplasms*
Carcinoma, Lobular
Colon*
Diagnosis
Drug Therapy
Female
Humans
Immunohistochemistry
Korea
Mastectomy, Modified Radical
Melena
Middle Aged
Neoplasm Metastasis*
Stomach*

Figure

• 

  Fig. 1 Microscopic findings. They show that the tumor cells of Invasive lobular carcinoma of breast arepositive for estrogen receptor (ER) and progesteron receptor (PR), Her2/neu. (A) Invasive lobular carcinoma of breast (H&E, ×100). (B) Invasive lobular carcinoma of breast (H&E, ×400). (C) Positive immunohistochemistry for ER (×400). (D) Positive immunohistochemistry for PR (×400). (E) Weakly positive immunohistochemistry for Her2/neu (×400).

• 

  Fig. 2 (A) Endoscopic finding. They show linitis plastica at the upper and middle of the stomach body. Elevated lesion with central depression is noted on the cardia. (B) Abdominal computed tomography scans show irregular wall thickening of gastric body and antrum. Circumferential wall thickening in rectosigmoid junction and upper rectum are also shown. (C) Sigmoidoscopy shows mucosal edema and irregular elevation of mucosa. Mild obstruction of colonic lumen is shown.

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  Fig. 3 Microscopic findings. They show that the tumor cells of metastatic breast carcinoma in stomach are positive for estrogen receptor (ER) and progesteron receptor (PR), Her2/neu. (A) Metastatic breast carcinoma in stomach (H&E, ×200). (B) Metastatic breast carcinoma in stomach (H&E, ×400). (C) Positive immunohistochemistry for ER (×400). (D) Positive immunohistochemistry for PR (×400). (E) Weakly positive immunohistochemistry for Her2/neu (×400).

• 

  Fig. 4 Microscopic findings. They show that the tumor cells of metastatic breast carcinoma in colon are positive for estrogen receptor (ER) and progesteron receptor (PR), Her2/neu. (A) Metastatic breast carcinoma in colon (H&E, ×200). (B) Metastatic breast carcinoma in colon (H&E, ×400). (C) Positive immunohistochemistry for ER (×400). (D) Positive immunohistochemistry for PR (×400). (E) Weakly positive immunohistochemistry for Her2/neu (×400).

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