Clin Psychopharmacol Neurosci.  2016 Feb;14(1):101-103. 10.9758/cpn.2016.14.1.101.

Metformin for Lithium-induced Weight Gain: A Case Report

Affiliations
  • 1Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India. samirpsyche@yahoo.co.in

Abstract

Lithium is the first line treatment for maintenance treatment of bipolar disorder. Among the long term adverse effects, weight gain is likely to affect a subset of patients. There is no specific guideline for the treatment of lithium-induced weight gain. We report a young male with bipolar disorder who had significant weight gain with lithium (25 kg), which responded to metformin treatment at 500 mg twice daily. The proposed mechanism of weight lowering effect of metformin includes changes in hypo-thalamic physiology, including leptin and insulin sensitivity, as well as circadian rhythm changes affecting food intake, regulation of fat oxidation and storage in liver, skeletal muscle, and adipose tissue.

Keyword

Lithium; Metformin; Weight gain; Antimanic

MeSH Terms

Adipose Tissue
Bipolar Disorder
Circadian Rhythm
Eating
Humans
Insulin Resistance
Leptin
Lithium
Liver
Male
Metformin*
Muscle, Skeletal
Physiology
Weight Gain*
Leptin
Lithium
Metformin
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