Infect Chemother.  2014 Dec;46(4):257-260. 10.3947/ic.2014.46.4.257.

A Case of Rectal Squamous Cell Carcinoma with Metachronous Diffuse Large B Cell Lymphoma in an HIV-Infected Patient

• Choi H
• Lee HW
• Ann HW
• Kim JK
• Kang HP
• Kim SW
• Ku NS
• Han SH
• Kim JM
• Choi JY

• KMID: 2170495
• DOI: http://doi.org/10.3947/ic.2014.46.4.257

Abstract

Diffuse large B cell lymphoma (DLBCL) is one of the most common acquired immune deficiency syndrome (AIDS)-defining malignancies among human immunodeficiency virus-infected patients, and rectal cancer has recently emerged as a prevalent non-AIDS-defining malignancy. We report a case of rectal squamous cell carcinoma that was metachronous with DLBCL in an HIV-infected patient who was receiving highly active antiretroviral therapy. The patient was diagnosed with DLBCL and showed complete remission after chemotherapy. Follow-up imaging showed increased uptake at the rectum, previously treated as lymphoma. Repeated biopsy was performed and squamous cell carcinoma of the rectum was reported. After concurrent chemoradiation therapy, curative resection was performed.

Keyword

HIV; AIDS-related lymphoma; Squamous cell carcinoma; Oncogenic viruses

MeSH Terms

Acquired Immunodeficiency Syndrome
Antiretroviral Therapy, Highly Active
Biopsy
Carcinoma, Squamous Cell*
Drug Therapy
Follow-Up Studies
HIV
Humans
Lymphoma
Lymphoma, AIDS-Related
Lymphoma, B-Cell*
Oncogenic Viruses
Rectal Neoplasms
Rectum

Figure

• 

  Figure 1 (A) 75% circumferential ulceroinfiltrative lesion in the rectum. (B) H&E stain (×400): Diffuse large B-cell lymphoma. (C) Immunohistochemical stain: CD 20 positive.

• 

  Figure 2 (A) Ulcerative polypoid lesion in the rectum. (B) H&E stain (×200): Squamous epithelial dysplasia, high grade. (C) H&E stain (×400): Squamous cell carcinoma.

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