Gut Liver.
2012 Jan;6(1):45-51.
The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma
- Affiliations
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- 1Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. endoscope@hanmail.net
- 2Division of Gastroenterology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
- 3Department of Pathology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
Abstract
- BACKGROUND/AIMS
Signal transducers and activators of transcription (STATs) are a family of transcription factors that are activated in response to cytokines and growth factors. STAT3 activation has been implicated in modulating the activity of downstream mediators, such as Bcl-xL and matrix metalloproteinase-2 (MMP-2). The aim of this study was to investigate the immunohistochemical expression of STAT3, B-cell lymphoma-extra large (Bcl-xL), and MMP-2 proteins according to histopathological parameters in colon adenocarcinomas, including lymph node metastasis, tumor differentiation, the TNM stage and the tumor size.
METHODS
Immunohistochemical staining with monoclonal STAT3, Bcl-xL, and MMP-2 antibodies was performed on paraffin-embedded specimens from 20 colon adenomas and 39 adenocarcinomas.
RESULTS
The expression of STAT3, Bcl-xL, and MMP-2 was increased in the adenocarcinomas as compared with the adenomas (p<0.001). STAT3 expression was stronger in tumors with a distant metastasis than in tumors without a distant metastasis (p=0.012). A larger tumor size was related to an increase in STAT3 expression (p=0.035).
CONCLUSIONS
STAT3, Bcl-xL, and MMP-2 may play important roles in the tumorigenesis of colorectal carcinoma. STAT3 may be indicative of a poor prognosis due to its correlation with distant metastases and a larger tumor size.
Keyword
MeSH Terms
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Adenocarcinoma
Adenoma
Antibodies
B-Lymphocytes
Cell Transformation, Neoplastic
Colon
Colorectal Neoplasms
Cytokines
Humans
Intercellular Signaling Peptides and Proteins
Lymph Nodes
Matrix Metalloproteinase 2
Neoplasm Metastasis
Prognosis
Proteins
Transcription Factors
Transducers
Antibodies
Cytokines
Intercellular Signaling Peptides and Proteins
Matrix Metalloproteinase 2
Proteins
Transcription Factors
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