Exp Neurobiol.  2013 Mar;22(1):18-22. 10.5607/en.2013.22.1.18.

Memantine Reverses Social Withdrawal Induced by Ketamine in Rats

Affiliations
  • 1Laboratorio de Neurofisiologia, Escuela De Ciencias Biomedicas y Tecnologicas Dr. Guillermo Mujica Sevilla, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. ezequiel.uribe@hotmail.com
  • 2Hospital Dr. Rafael Gonzalez Plaza, Departamento de Neuropsiquiatria. INSALUD, Gobernacion del Estado Carabobo. Edo. Carabobo 2001, Venezuela.

Abstract

The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg.kg(-1)) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg.kg(-1)) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.

Keyword

experimental psychosis; ketamine; NMDA; haloperidol; social interaction test

MeSH Terms

Animals
Haloperidol
Interpersonal Relations
Ketamine
Memantine
Motor Activity
N-Methylaspartate
Rats
Schizophrenia
Haloperidol
Ketamine
Memantine
N-Methylaspartate
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