Psychiatry Investig.  2013 Dec;10(4):421-424.

A 10-Week Memantine Treatment in Bipolar Depression: A Case Report. Focus on Depressive Symptomatology, Cognitive Parameters and Quality of Life

Affiliations
  • 1Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. dominik.strzelecki@umed.lodz.pl
  • 2Central Clinical Hospital, Lodz, Poland.
  • 3Department of Adolescent Psychiatry, Medical University of Lodz, Lodz, Poland.

Abstract

Memantine and other glutamatergic agents have been currently investigated in some off-label indications due to glutamatergic involvement in several psychoneurological disorders. We assumed that memantine similarly to ketamine may positively influence mood, moreover having a potential to improve cognition and general quality of life. We report a case of a 49-year-old male hospitalized during a manic and a subsequent moderate depressive episode. After an ineffective use of lithium, olanzapine and antidepressive treatment with mianserin, memantine was added up to 20 mg per day for 10 weeks. The mental state was assessed using the Hamilton Depression Rating Scale, the Young Mania Rating Scale, the Hamilton Anxiety Scale, the Clinical Global Inventory, the World Health Organization Quality of Life Scale and psychological tests. After 10 weeks the patient achieved a partial symptomatic improvement in mood, anxiety and quality of sleep, but his activity remained insufficient. We also observed an improvement in the parameters of cognitive functioning and quality of life. There was neither significant mood variations during the memantine use nor mood changes after its termination. No significant side effects were noted during the memantine treatment. We conclude that using memantine in bipolar depression may improve mood, cognitive functioning and quality of life.

Keyword

Memantine; Bipolar disorder; Depression; Cognitive functioning; Glutamate

MeSH Terms

Anxiety
Bipolar Disorder*
Cognition
Depression
Excitatory Amino Acid Agents
Glutamic Acid
Humans
Ketamine
Lithium
Male
Memantine*
Mianserin
Middle Aged
Psychological Tests
Quality of Life*
World Health Organization
Excitatory Amino Acid Agents
Glutamic Acid
Ketamine
Lithium
Memantine
Mianserin
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