Ann Dermatol.  2012 Feb;24(1):87-89. 10.5021/ad.2012.24.1.87.

Lichen Striatus Occurring after Allogenic Peripheral Blood Stem Cell Transplantation in an Adult with Aplastic Anemia

• Mun JH
• Park HJ
• Kim HS
• Kim SH
• Ko HC
• Kim BS
• Kim MB

• KMID: 2156864
• DOI: http://doi.org/10.5021/ad.2012.24.1.87

Abstract

Lichens striatus (LS) is an acquired, self-limiting inflammatory dermatosis that follows the lines of Blaschko. The etiology of the eruption is unknown, but several theories have been proposed with focus on environmental factors, viral infection, cutaneous injury, hypersensitivity, and genetic predisposition. We describe a 19-year-old woman who developed a unilateral linear eruption 17 months after allogenic peripheral blood stem cell transplantation. Histopathology revealed features, which were consistent with LS. To the best of our knowledge, our patient is the first case describing the appearance of LS occurring after allogenic stem cell transplantation. We speculate that this condition represents an unusual form of localized, chronic graft-versus-host disease.

Keyword

Graft-versus-host disease; Lichen striatus; Pathogenesis; Stem cell transplantation

MeSH Terms

Adult
Anemia, Aplastic
Female
Genetic Predisposition to Disease
Graft vs Host Disease
Humans
Hypersensitivity
Lichens
Peripheral Blood Stem Cell Transplantation
Skin Diseases
Stem Cell Transplantation
Young Adult

Figure

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  Fig. 1 Linear brownish to erythematous papules along the left back and arm following the Blaschko line.

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  Fig. 2 Histopathologic examination of papules shows the presence of an epidermal hyperkeratosis, exocytosis, necrotic keratinocytes and superficial perivascular infiltrates of lymphocytes and histiocytes in the dermis (H&E, ×200).

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  Fig. 3 Proposed pathogenesis of lichen striatus.

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