Clinical Experiences of 118 Cases Primary Living-Donor Renal Transplantations

Kim, Chan Young; Yu, Hee Chul; Cho, Baik Hwan; Kim, Jae Chun; Kang, Nam Poo

Abstract

From Feburary 1989 to December 1997, 118 cases of primary living-donor renal transplantations were performed in Chonbuk National University Hospital. We analyzed the outcome of grafts and the potential risk factors that could influence the graft survival. The results were as follows. Male versus female ratio of recipients and donors were 3.2:1 and 1.1:1, and the mean age of them were 33.4 years and 44.8 years, respectively. Overall graft and patient survival rates were 95.7%, 97.4% at 1 year, 90.8%, 93.5% at 3 year, and 87.7%, 93.5% at 5 year, respectively. In all, 16 cases (13.6%) were lost during the observation period, with the most common causes of graft loss being chronic renal failure (10 cases, 63%), death with a functioning graft (3 cases, 19%), acute renal failure, anastomotic infection, and spontaneous renal rupture in each other one case. The deaths of patients occured in 9 cases (7.6%). The most common causes were pneumonia (5 cases, 56%), and the others were sepsis, breast cancer, retroperitoneal hematoma, and multiple organ failure in each other one case, respectively. The analyzed variables that could affect the graft survival were HLA typing, relative relationship, ABO typing, pretransplant blood transfusion, prevalence of CRF, acute rejection, and frequency of rejection episodes, but the results were not statistically significant. According to the relative relationship, acute rejection rate was 28.4% (25 of 88 cases) in relative, and 59.3% (16 of 27 cases) in non-relative. And so relative relationship influenced the acute rejection rates (p=0.003).