Korean J Med.
2010 Feb;78(2):177-184.
Combination therapy of hypertension
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- 1Cardiovascular Center, Ewha Womans University Mokdong Hospital, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Abstract
- Hypertension is one of the most common preventable disease for premature death in worldwide. In Korea, the prevalence rate of hypertension is 24.9% in adult. The pathophysiology of the hypertension is complicated including genetics, aging, sympathetic nervous system, renin-angiotensin-aldosterone system, metabolism and nutrition. The combination therapy for blocking these complex systems is effective. Recent clinical studies showed angiotensin converting enzyme inhibitor and calcium channel blocker was more effective than the old drug combination such as beta blocker and diuretics. For improving compliance, fixed-dose drug combination is recommended. For the effect of treatment, simple guideline is essential.
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