Correlation between DNA ploidy, pathological stage and prognosis in renal cell carcinoma

Suh, Jang Ki; Park, Yang Il

Abstract

The correlation between deoxyribonucleic acid (DNA) ploidy, pathological stage and prognosis was evaluated in 18 patients, who underwent nephrectomy and proved to be renal cell carcinoma. Of them, 10 (56%) cases showed a DNA diploid pattern and 8 (44% ) cases a DNA aneuploid one. The pathologic stage and DNA ploidy. revealed aneuploid tumors in 2(29%) of 7 patients with stage pT1-2N0M0(group 1). in 2 (33%) of 6 patients with stage pT3aN0M0 (group 2) and in 4 (80%) of 5 patients with stage pT3bN02M0.(group 3) respectively. The Mean follow up period was 3.3 years. The number of the survivals more than 2 years were 12(67%). comprising 8 of diploid tumors and 4 of aneuploid tumors, suggesting that patients with diploid tumor survived longer than those with aneuploid tumor. The survivals more than 2 years in relation to pathological stage were 6 (86%) or 7 patients with group 1, 5(83%) of 6 with group 2 and 1 (20%) of 5 with group 3, respectively. The S phase fraction showed no significant difference between diploid and aneuploid tumors, but the survivals more than 2 years had significantly lower S phase fraction than those less than 2 years. The results suggest that DNA ploidy correlates with pathologic stage and prognosis. and S phase fraction may influence the prognosis independently.