Korean J Pathol.  1999 Nov;33(11):1061-1066.

Correlation of Clinical Stage and Presumptive Prognostic Factors in Renal Cell Carcinoma

• Yoo JY
• Cho HJ

Abstract

Renal cell carcinoma is the most common primary cancer of the kidney. The tumor stage is a reliable prognostic marker in renal cell carcinoma which is significantly associated with patient survival. But assessment of other prognostic factors has produced varying and often conflicting
results
. We reevaluated the significance of varied prognostic parameters in 33 cases of renal cell carcinoma; clinical stage, cell type, histologic pattern, DNA ploidy, Ki-67 labeling index, and bcl-2 oncoprotein expression. We could not statistically prove that DNA ploidy and bcl-2 expression were related to any examined parameters. Cell type was not related to clinical stage nor nuclear grade but there was a significant correlation (p=0.002) between cell type and histologic pattern. Nuclear grade (p=0.007) and Ki-67 labeling index (p=0.036) were significantly related to clinical stage, suggesting their value as complementary prognostic markers for renal cell carcinoma.

Keyword

Renal cell carcinoma; Stage; Nuclear grade; Ki-67 labeling index; Bcl-2 expression

MeSH Terms

Carcinoma, Renal Cell*
DNA
Humans
Kidney Neoplasms
Ploidies
DNA