J Korean Neurosurg Soc.  2013 Nov;54(5):420-422. 10.3340/jkns.2013.54.5.420.

Lymphomatosis Cerebri

• Choi CY
• Lee CH
• Joo M

• KMID: 2138359
• DOI: http://doi.org/10.3340/jkns.2013.54.5.420

Abstract

Lymphomatosis cerebri is considered a diffuse form of primary central nervous system lymphoma and very rare. It is not well recognized and may be misdiagnosed with infiltrating tumors, degenerative disorders, ischemic diseases, and infectious diseases developed in the brain. Awareness of the possibility of this rare disease and early biopsy are required for differential diagnosis and preventing poor clinical outcomes. We report a case with lymphomatosis cerebri who presented with rapid neurological deteriorations and review the relevant literatures.

Keyword

Lymphomatosis cerebri; Primary central nervous system lymphoma; Biopsy

MeSH Terms

Biopsy
Brain
Central Nervous System
Communicable Diseases
Diagnosis, Differential
Lymphoma
Rare Diseases

Figure

• 

  Fig. 1 MRI shows diffuse, poorly-circumscribed T2 hyper-intense lesions which involve the brainstem and deep regions in both cerebral hemispheres at presentation (A and B). These lesions are not enhanced with Gadolinium (C). Two months later, these lesions extend into both thalamus and periventricular deep white matters (D and E). Definite enhancement is still not noted (F).

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  Fig. 2 H&E microphotograph displays scattered atypical lymphocytes and perivascular lymphoid cells (A). On immunohistochemical staining, atypical lymphoid cells are strongly stained with CD20 (B).

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