Allergy Asthma Immunol Res.  2011 Apr;3(2):128-131. 10.4168/aair.2011.3.2.128.

Two Cases of H2-Receptor Antagonist Hypersensitivity and Cross-Reactivity

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. addchang@snu.ac.kr
  • 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
  • 3Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.
  • 4Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea.
  • 5Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

H2-receptor antagonists, such as cimetidine, ranitidine and famotidine, are some of the most commonly prescribed medications for gastric acid-related disorders. These compounds are generally well-tolerated and anaphylactic reactions to them are rare. Here, we report two cases of H2-receptor antagonist-induced anaphylactic reactions: the first presented with sudden dyspnea, sneezing, urticaria, and swelling of the eyelids after ranitidine intake. The second presented with sudden severe urticaria, facial swelling, chest discomfort, dizziness, and hypotension. Possible cross-reactivity with other H2-receptor antagonists was assessed by oral challenge and skin tests. To date, only a few reports addressing cross-reactivity among H2-receptor antagonists have been published. We review the literature and summarize the data available on drug cross-reactivity in H2-receptor antagonist hypersensitivity.

Keyword

Histamine H2 receptor antagonists; cross reactions; drug hypersensitivity; allergy

MeSH Terms

Anaphylaxis
Cimetidine
Cross Reactions
Dizziness
Drug Hypersensitivity
Dyspnea
Eyelids
Famotidine
Histamine H2 Antagonists
Hypersensitivity
Hypotension
Ranitidine
Skin Tests
Sneezing
Thorax
Urticaria
Cimetidine
Famotidine
Histamine H2 Antagonists
Ranitidine

Figure

  • Figure Chemical structures of H2-receptor antagonists.


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Reference

1. Kim YI, Park CK, Park DJ, Wi JO, Han ER, Koh YI. A case of famotidine-induced anaphylaxis. J Investig Allergol Clin Immunol. 2010; 20:166–169.
2. Levine M, Law EY, Bandiera SM, Chang TK, Bellward GD. In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats. J Pharmacol Exp Ther. 1998; 284:493–499.
3. Mills JG, Koch KM, Webster C, Sirgo MA, Fitzgerald K, Wood JR. The safety of ranitidine in over a decade of use. Aliment Pharmacol Ther. 1997; 11:129–137.
4. Howden CW, Tytgat GN. The tolerability and safety profile of famotidine. Clin Ther. 1996; 18:36–54. discussion 35.
5. Walker AI, Werfel S, Kick G, Przybilla B. Repeated anaphylactic responses induced by oral challenge with ranitidine. Acta Derm Venereol. 2010; 90:189.
6. Thurot-Guillou C, Bourrain JL, Jacquier JP, Beani JC. Anaphylactic reaction to ranitidine and dexchlorpheniramine. Eur J Dermatol. 2007; 17:170–171.
7. Rethnam U, Yesupalan RS. Anaphylactic reaction associated with Ranitidine in a patient with acute pancreatitis: a case report. J Med Case Reports. 2007; 1:75.
8. Koh YI, Park HS, Choi IS. Ranitidine-induced anaphylaxis: detection of serum specific IgE antibody. Allergy. 2006; 61:269–270.
9. Demirkan K, Bozkurt B, Karakaya G, Kalyoncu AF. Anaphylactic reaction to drugs commonly used for gastrointestinal system diseases: 3 case reports and review of the literature. J Investig Allergol Clin Immunol. 2006; 16:203–209.
10. Mira-Perceval JL, Ortiz JL, Sarrió F, Miralles JC, Hernández J, Negro-Alvarez JM, López-Sánchez JD, García-Sellés FJ, Pagán JA. Nizatidine anaphylaxis. J Allergy Clin Immunol. 1996; 97:855–856.
11. Lazaro M, Compaired JA, De La Hoz B, Igea JM, Marcos C, Dávila I, Losada E. Anaphylactic reaction to ranitidine. Allergy. 1993; 48:385–387.
12. Morisset M, Moneret-Vautrin DA, Loppinet V, Grandidier S. Cross-allergy to ranitidine and nizatidine. Allergy. 2000; 55:682–683.
13. Bossi A, Romeo G, Pezzoli A. Side-effects, structure, and H2-receptor antagonists. Lancet. 1992; 339:1366.
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