J Asthma Allergy Clin Immunol.  2004 Mar;24(1):146-151.

Anaphylactoid reaction to ofloxacin with cross-reactivity to other fluoroquinolones

Affiliations
  • 1Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea. cwkim1805@inha.ac.kr

Abstract

Fluoroquinolones are antimicrobial agents that have a broad range of activity against both gram-negative and gram-positive organisms. Anaphylactoid reactions have been sporadically reported with fluoroquinolones. There have been a few reports that describes cross-reactivity between fluoroquinolones. We experienced a case of ofloxacin-induced anaphylactoid reaction, and confirmed cross-reactivity between ofloxacin and ciprofloxacin with the oral challenge test. Cross-reactivity between fluoroquinolones may be important, and avoidance of any fluoroquinolones should be mandatory for patients with hypersensitivity reaction to one of these drugs.

Keyword

Anaphylatoid reaction; ofloxacin; fluoroquinolones; cross-reactivity
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