Korean J Vet Res.
2015 Mar;55(1):57-60. 10.14405/kjvr.2015.55.1.57.
Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice
- Affiliations
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- 1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea. beomjun@cbu.ac.kr, ywyun@cbu.ac.kr
- 2College of Veterinary Medicine and Institute of Life Science, Gyeongsang National University, Jinju 600-701, Korea.
- KMID: 2128681
- DOI: http://doi.org/10.14405/kjvr.2015.55.1.57
Abstract
- To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 microCi/mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. 177Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
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