J Korean Ophthalmol Soc.
1988 Oct;29(5):809-813.
The Concentration of Tobramycin in Cornea and Sclera After Subconjunctival Injection of Liposome-encapsulated Tobramycin in Rabbits
- Affiliations
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- 1Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
- The authers investigated the effct of liposome encapsulation on the pharmacokinetics of tobramycin after subconjuctival in jnjection in rabbits. Tobramycin was encapsulated into neutral liposomes of phosphatidylcholine and cholesterol. The final liposomal suspension contained tobramycin, 5mg/ml. One of the each rabbit received a subconjunctival injection(2.5mg/0.5ml) of liposome-encapsulated tobramycin or tobramycin alone. Tobramycin levels in the sclera measured 3 and 24 hours after injection were marked higher with the liposome-encapsulated drug than with the another preperation. The difference between liposomeencapsulated drug and the another preperation was not significant for cornea.
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