Korean J Otolaryngol-Head Neck Surg.  1999 Aug;42(8):1041-1045.

Epstein Barr Virus-Associated Angiocentric T Cell Lymphoma in Nasal Cavity of Renal Transplantation Recipient

• Kang HW
• Lee JE
• Park JS
• Lee SS

Abstract

Posttransplant lymphoproliferative disorder (PTLD)is recognized as a significant and morbid complication of organ transplantation. The majority of PTLD is of B cell origin and strongly associated with Epstein Barr virus (EBV). T cell origin is uncommon and has a poor prognosis. There are only a few cases of PTLD of T cell origin, associated with EBV. We have experienced a case of angiocentric T cell lymphoma in nasal cavity, associated with EBV in a renal transplanted recipient. The patient was 25 years old woman who received transplant from her brother in 1995. Angiocentric T cell lymphoma was developed 33 months after the transplantation. We detected EBV mRNA in the neoplastic cells by in situ hybridization. She was treated by radiotherapy and is in complete remission state at present.

Keyword

PTLD(Posttransplant lymphoproliferative disorder); Angiocentric T cell lymphoma; Epstein barr virus

MeSH Terms

Adult
Female
Herpesvirus 4, Human
Humans
In Situ Hybridization
Kidney Transplantation*
Lymphoma, T-Cell*
Lymphoproliferative Disorders
Nasal Cavity*
Organ Transplantation
Prognosis
Radiotherapy
RNA, Messenger
Siblings
Transplants
RNA, Messenger