Korean J Otolaryngol-Head Neck Surg.  2000 May;43(5):501-506.

Angiocentric Immunoproliferative Lesions of the Nasal Cavity

• Ye MK
• Lee CH
• Park JS

Abstract

BACKGROUND AND OBJECTIVES: In the past years angiocentric immunoproliferative lesion was described as various terms and histologically characterized by polymorphism, angiodestruction, and necrosis. This study was carried out to analyze the clinical profile, the results of treatment, and immunohistochemical nature of the angiocentric immunoproliferative lesion of the nasal cavity. In addition, we aimed to estimate the significance of Epstein-Barr virus infection as a causative agent in this disease. MATERIAL AND METHODS: We performed clinical and pathologic review of patients with the destructive sinonasal lesions, who were treated at the department of Otolaryngology, Kyungpook National University. Immunohistochemical staining was done in 28 cases and EBER in situ hybridization was done in 14 cases.
RESULTS
The overall five-year survival rate was 62%. Immunohistochemical study showed positive reaction to the T-cell surface marker and Epstein-Barr virus was detected in all tested cases.
CONCLUSION
Nasal cavity AIL was non-Hodgkin's lymphoma, and of T-cell origin, and was closely related with the Epstein- Barr virus infection. It may be worthwhile to evaluate its pathogenesis in relation with Epstein-Barr virus infection and study the appropriate treatment method.

Keyword

Angiocentric immunoproliferative lesion; Non-Hodgkin's lymphoma; T-cell Epstein-Barr virus

MeSH Terms

Gyeongsangbuk-do
Herpesvirus 4, Human
Humans
In Situ Hybridization
Lymphoma, Non-Hodgkin
Nasal Cavity*
Necrosis
Otolaryngology
Survival Rate
T-Lymphocytes