J Korean Pediatr Soc.  2003 Mar;46(3):230-235.

The Significances of Chest X-ray Findings and Serum IFN-gamma, IL-5, ECP as Predictors of Prognosis of Bronchiolitis and Bronchopneumonia in Infants

• Cho SH
• Lee HS
• Lee MH
• Lee JS

Abstract

PURPOSE
Lower respiratory tract infections in infant and young children are often due to a virus, especially the Respiratory syncytial(RS) virus. Chest X-ray findings in bronchiolitis and bronchopneumonia are different. The radiographic hallmark of bronchiolitis is pulmonary hyperinflation and similar to that of bronchial asthma. Bronchiolitis is predisposed to later development of bronchial asthma. To evaluate the difference of immuno-pathophysiology between bronchiolitis and bronchopneumonia, we measured IFN-gamma (Th1 cytokine), IL-5(Th2 cytokine) and ECP. We also investigated whether X-ray findings in infants with viral infected respiratory disease are useful in predicting the development of asthma.
METHODS
We measured IL-5, ECP, IFN-gamma levels in serum from 21 infants with bronchiolitis and 21 infants with bronchopneumonia and 16 infants without pulmonary viral diseases.
RESULTS
IL-5 levels of bronchiolitis and bronchopneumonia were significantly higher than those of the control(P=0.02, P=0.042). IL-5 levels of bronchiolitis were higher than those of bronchopneumonia but there was no significant difference. IFN-gamma levels of bronchopneumonia were higher than those of bronchiolitis but there was no significant difference. ECP levels of bronchiolitis and bronchopneumonia were higher than those of the control but only those of bronchiolitis were significantly higher than those of the control(P=0.045). IL-5 and ECP levels did not show any significant correlation in bronchiolitis, bronchopneumonia and control groups.
CONCLUSION
We cannot prove the distinct differences in serum Th1/Th2 cytokine profiles between bronchiolitis and bronchopneumonia in infants. These results suggest that the different findings on chest X-ray between bronchiolitis and bronchopneumonia could not be a predictor of later development of asthma.

Keyword

Bronchiolitis; Bronchopneumonia; Chest X-ray; IL-5; IFN-gamma; ECP

MeSH Terms

Asthma
Bronchiolitis*
Bronchopneumonia*
Child
Humans
Infant*
Interleukin-5*
Prognosis*
Respiratory Tract Infections
Thorax*
Virus Diseases
Interleukin-5