J Korean Radiol Soc.  2000 Jan;42(1):15-21. 10.3348/jkrs.2000.42.1.15.

Effect of Steroid on Brain Tumors and Surround Edemas: Observa tion with Regional Cere b ral Blood Volume (rCBV) Maps of Perfusion MRI

Affiliations
  • 1Department of Diagnostic Radiology, Ajou University, School of Medicine.
  • 2Department of Neurosurgery, Ajou University, School of Medicine, Korea.
  • 3Department of Neurology, Ajou University, School of Medicine, Korea.

Abstract

PURPOSE
To observe the hemodynamic change in brain tumors and peritumoral edemas after steroid treat-ment, and then nvestigate the clinical usefulness of perfusion MRI. MATERIALS AND METHODS: We acquired conventional and perfusion MR images in 15 patients with various in-tracranial tumors (4 glioblastoma multiformes, 4 meningiomas, 3 metastatic tumors, 1 anaplastic ependymo-ma, 1 anaplastic astrocytoma, 1 hemangioblastoma, and 1 pilocytic astrocytoma). For perfusion MR imaging, a 1.5T unit employing the gradient-echo EPI technique was used, and further perfusion MR images were ob-tained 2-10 days after intravenous steroid therapy. After processing of the raw data, regional cerebral blood volume (rCBV) maps were reconstructed. The maps were visually evaluated by comparing relative perfusion in brain tumors and peritumoral edemas with that in contralateral white matter. Objective evaluations were performed by comparing the perfusion ratios of brain tumors and peritumoral edemas.
RESULTS
Visual evaluations of rCBV maps, showed that in most brain tumors (67%, 10/15), perfusion was high before steroid treatment and showed in (80%, 12/15) decreased afferwards. Objective evaluation, showed that in all brain tumors, perfusion decreased. Visual evaluation of perfusion change in peritumoral edemas revealed change in only one case, but objective evaluation indicated that perfusion decreased signifi-cantly in all seven cases.
CONCLUSIONS
rCBV maps acquired by perfusion MR imaging can provide hemodynamic information about brain tumors and peritumoral edemas. Such maps could prove helpful in the preoperative planning of brain tumor surgery and the monitoring of steroid effects during conservative treatment.

Keyword

Magnetic resonance (MR), image processing; Brain neoplasms, MR; Steroids

MeSH Terms

Astrocytoma
Blood Volume*
Brain Neoplasms*
Brain*
Edema*
Glioblastoma
Hemangioblastoma
Hemodynamics
Humans
Magnetic Resonance Imaging*
Meningioma
Perfusion*
Steroids
Steroids
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