J Korean Soc Neonatol.  2008 May;15(1):54-60.

Changes in Pathogens and Antibiotic Sensitivities in very Low Birth Weight Infants with Neonatal Sepsis

• Kim KN
• Park HJ

Abstract

PURPOSE: To set up an appropriate treatment plan for neonatal sepsis by investigating changes in pathogens and antibiotic sensitivities.
METHODS
The medical records of very low birth weight infants (VLBWI) admitted to the neonatal intensive care unit (NICU) of the Eulji University Hospital between January 2000 and June 2006 were retrospectively reviewed. The culture reports were analyzed for causative microorganisms and antibiotic sensitivities.
RESULTS
Among 164 neonates, 19 neonates (11.6%) had 26 episodes of culture-proven sepsis. Very late onset sepsis was the most common type. The dominant pathogens of sepsis included Klebsiella pneumoniae, Streptococcus spp., coagulase negative Staphylococcus and Enterobacter spp., and were mostly multi-drug resistant.
CONCLUSION
For the appropriate treatment of neonatal sepsis, proper use of antibiotics through the periodic review and understanding of changes of the microorganisms and antimicrobial sensitivities is necessary to prevent multi-drug resistant microorganisms and to avoid excessive use of broad-spectrum empiric antibiotics.

Keyword

Neonatal sepsis; Antimicrobial sensitivity; Neonatal intensive care unit

MeSH Terms

Anti-Bacterial Agents
Coagulase
Enterobacter
Humans
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care, Neonatal
Klebsiella pneumoniae
Medical Records
Retrospective Studies
Sepsis
Staphylococcus
Streptococcus
Anti-Bacterial Agents
Coagulase