J Korean Soc Pediatr Nephrol.
2004 Oct;8(2):129-137.
Efficacy and Safety during the Combination Therapy of Imipramine and Desmopressin in Primary Monosymptomatic Nocturnal Enuresis
- Affiliations
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- 1Department of Pediatrics, College of Medicine Yeungnam University, Daegu, Korea. yhpark@med.yu.ac.kr
- 2Department of Preventive Medicine, College of Medicine Yeungnam University, Daegu, Korea.
- 3Department of Pediatrics, Kyungpook National University Hospital, Daegu, Korea.
- 4Department of Pediatrics, College of Medicine, KonKuk University, Seoul, Korea.
- 5Department of Pediatrics, NHIC Ilsan Hospital, Koyang, Korea.
- 6Department of Pediatrics, Cheong Ju St. Mary's Hospital, Cheong Ju, Korea.
- 7Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 8Department of Pediatrics, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea.
- 9Department of Pediatrics, Ajou UniversitySchool of Medicine, Suwon, Korea.
- 10Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
- 11Department of Pediatrics, The Catholic University of Korea, College of Medicine, Seoul, Korea.
- 12Department of Pediatrics, Chonbuk National University College of Medicine, Jeonju, Korea.
- 13Department of Pediatrics, College of Medicine Ewha Womans University, Seoul, Korea.
- 14Department of Pediatrics, Presbyterian Medical Center, Chonju, Korea.
- 15Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- 16Department of Pediatrics, Hallym University, College of Medicine, Chuncheon, Korea.
- 17Department of Pediatrics, Fatima Hospital, Daegu, Korea.
- 18Department of Pediatrics, Inje University College of Medicine, Pusan, Korea.
- 19Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea.
Abstract
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PURPOSE: Nocternal enuresis is a common disorder. Tricyclic antidepressant and desmopressin have been accepted pharmacological treatment for this disorder. We conducted a cooperative study to investigate the efficacy and adverse reactions of imipramine, desmopressin and combination treatment in children with primary monosymptomatic nocturnal enuresis(PMNE).
METHODS
Data from a large multicenter study were analysed. In the period of 8 months in 2002, the study comprised of 168 children(78 boys and 90 girls, 5 to 15 years old) with PMNE for imipramine, desmopressin or combination treatment. Before treatment a history, physical examination and laboratory tests were performed and the children were observed for 2 weeks. Response rate, adverse reactions and enuresis episodes after stopping drug administration were evaluated after 12-weeks of imipramine, desmopressin or combination of both.
RESULTS
After 4 weeks, the frequency of bed wetting in all treated patients decreased during treatment significantly. Even though a 30-50% reduction in the number of wet nights were 68.6%, 74.4% and 86.1% during 12 weeks treatment by imipramine, desmopressin and both of them respectively, there was no significant difference between them. The most common adverse reaction was decreased appetite from imipramine administration. But no serious drug-related adverse events were reported.
CONCLUSION
Efficacy of the combination therapy of imipramine and desmopressin in PMNE appears not to be better than either drug alone. It is necessary to pay attention on account of adverse reactions during imipramine treatment even though imipramine and desmopressin were generally well tolerated.
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