J Korean Soc Transplant.  2009 Sep;23(2):149-153. 10.4285/jkstn.2009.23.2.149.

Comparison of New Onset Diabetes according to the Time of Onset in Kidney Transplant Recipients

Affiliations
  • 1Department of Surgery, University of Hallym College of Medicine, Seoul, Korea. slee@hallym.or.kr
  • 2Transplantation Center of Kang-dong Sacred Heart Hospital, Seoul, Korea.

Abstract

BACKGROUND
New onset diabetes is a common complication after kidney transplantation. However, the clinical course of post-transplant diabetes mellitus (PTDM) remains unclear. The aim of the present study is to analyze the natural courses and risk factors of PTDM according to the time of onset.
METHODS
A total of 216 consecutive kidney transplant recipients were enrolled and patient medical records were investigated retrospectively. PTDM was defined as glucose > or =126mg without previous diabetic history. Patients were classified according to the onset (12 months): early PTDM (E-PTDM) and late PTDM (L-PTDM).
RESULTS
PTDM was observed in 34 (17.4%) patients. The number of E-PTDM and L-PTDM patients was 17 and 17. Compared with normoglycemic patients, the PTDM group was older and showed higher pre-transplant HbA1c level. The use of tacrolimus was associated with the development of E-PTDM (OR=4.87, 1.71~13.8 in 95% CI) but not L-PTDM (OR=0.34, 0.04~2.70 in 95% CI)
CONCLUSIONS
The development of E-PTDM and L-PTDM may have different risk factors. It will be important to choose different therapeutic strategy according to the onset of PTDM.

Keyword

Renal transplantation; Post-transplantation diabetes mellitus; Risk factor
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