Korean J Anat.
2000 Feb;33(1):13-20.
Gene Expression of NeuroD/BETA2 during Development of the Mouse Central Nervous System
- Affiliations
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- 1Department of Anatomy, School of Medicine, Ajou University, Suwon 442-749, Korea.
- 2Laboratory of Gene therapy, Korea Institute of Bioscience and Biotechnology, Taejon 305-600, Korea.
Abstract
- NeuroD/BETA2, a basic helix-loop-helix transcription factor, has been known to play a role in terminal differentia-tion during neurogenesis. To gain further insight into the function of NeuroD/BETA2 in the nervous system devel-opment, we examined the expression pattern of NeuroD/BETA2 during embryonic and postnatal development by in situ hybridization. Dynamic changes of NeuroD/BETA2 expression were observed in the developing nervous system. Gene expression of the NeuroD/BETA2 in developing cerebellum and hippocampus increased during the embryonic stages and persisted throughout postnatal development and remained at a stable level in the adult brain. NeuroD/ BETA2 expression was detected in postmitotic cells in the subventricular zone of the cerebrum during embryogenesis. This observation confirms that NeuroD/BETA2 may have a role in terminal differentiation during neurogenesis.
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