Korean J Hematol.  2002 May;37(2):134-137.

A Case of Bone Marrow Involvement of Hepatosplenic gamma delta-Cell Lymphoma

Affiliations
  • 1Department of Clinical Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea. sunnyhk@smc.samsung.co.kr
  • 2Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 3Department of Diagnostic Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Hepatosplenic gamma delta-cell lymphoma is a rare histologic type of peripheral T-cell lymphomas, clinically characterized by predominant involvement of liver and spleen, no or little adenopathy, and an often aggressive course. We report a case of bone marrow involvement of hepatosplenicgamma delta-cell lymphoma in a 21- year-old woman who presented with fever, anemia, thrombocytopenia, and hepatosplenomegaly. A lymphoma was found subsequently by bone marrow biopsy and computed tomography scan of the abdomen and pelvis. Immunologic characterization of lymphoma cells in bone marrow revealed positivity for CD2, CD3, and CD16/56, and negativity for CD4, CD5, CD7, CD8, CD34, and terminal deoxynucleotidyl transferase (TdT). Conventional cytogenetic studies revealed the presence of isochromosome 7q. Using the PCR-SSCP technique, monoclonal gene rearrangement of the T-cell receptor gamma chain was demonstrated. Thus, we could make a confirmatory diagnosis as hepatosplenic gamma delta-cell lymphoma.

Keyword

Hepatosplenic; gamma delta-cell; Peripheral T-cell lymphoma; Isochromosome 7q; T-cell receptor

MeSH Terms

Abdomen
Anemia
Biopsy
Bone Marrow*
Cytogenetics
Diagnosis
DNA Nucleotidylexotransferase
Female
Fever
Gene Rearrangement
Humans
Isochromosomes
Liver
Lymphoma*
Lymphoma, T-Cell, Peripheral
Pelvis
Receptors, Antigen, T-Cell
Spleen
Thrombocytopenia
DNA Nucleotidylexotransferase
Receptors, Antigen, T-Cell
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