Korean J Med.
2009 Apr;76(Suppl 1):S87-S92.
Pulmonary tumor thrombotic microangiopathy in a patient with breast cancer
- Affiliations
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- 1Department of Internal Medicine, Bundang CHA Hospital, College of Medicine, Pochon CHA University, Seongnam, Korea.
- 2Department of Division of Cardiology, Bundang CHA Hospital, College of Medicine, Pochon CHA University, Seongnam, Korea. Injaikim@cha.ac.kr
- 3Department of Pathology, Bundang CHA Hospital, College of Medicine, Pochon CHA University, Seongnam, Korea.
Abstract
- Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare malignancy-related complication causing severe pulmonary hypertension, right heart failure, and death. PTTM is characterized by diffuse fibrocellular intimal proliferation and multiple thrombi formation in the pulmonary arteries and arterioles, which result from invasion of the pulmonary blood vessels by tumor cells. Establishing the diagnosis of PTTM is very difficult and few cases are diagnosed ante mortem. We report the case of a 48-year-old woman diagnosed with PTTM before death who developed breast cancer and presented with persistent dyspnea on exertion.
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