Korean J Med.
1998 Apr;54(4):568-571.
A Case of Diabetes Insipidus Following Tuberculous Meningitis
- Affiliations
-
- 1Department of Internal Medicine, Presbyterian Medical Center, Cheon Ju, Korea.
Abstract
-
Tuberculous menigitis is relatively common disease
and delay in treatment is associated with many neurologic
sequelae. Of the neurologic disorder, diabets insipidus is
extreamly rare.
Diabetes insipidus is a syndrome characterized by the
excretion of abnormally large volumes of dilute urine. It is
divided into central diabets insipidus, nephrogenic diabetes
insipidus, primary polydipsia and gestational daibetes
insipidus. In this four type of diabetes insipidus, central
diabetes insipidus is a polyuric disorder results from a lack
of sufficient antidiuretic hormone to effect appropriate
concentration of the urine for water conservration.
We report a 25-year old male who had prolonged head
ache and subsequently followed by polyuria. He was dia
gonsed as the tuberculous meningitis by laboratory find
ing and smear of CSF, and diagnosed central diabetes
insipidus by serum osmolality & Na+ & AVP (arginine va
sopressin), urine osmolality & specific gravity, adminis
tration of vasopressin. He maintained the water balance
of body by administration of vasopressin, but without im
provement of mental status, sudden cardiac arrest occurs
on 20th hospital day