Kosin Med J.
2011 Jun;26(1):98-102.
Central Diabetes Insipidus Occurring during Therapy for Tsutsugamushi Disease
- Affiliations
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- 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. aiteite1@naver.com
Abstract
- Tsutsugamushi disease (Scrub typhus) is an acute febrile illness caused by infection with Orientia tsutsugamushi and characterized by focal or disseminated vasculitis, which may involve the lungs, heart, liver and central nervous system. Tsutsugamushi meningitis are reported worldwide, but central diabetes insipidus associated with CNS involvement have not been reported. A 53-year-old female diagnosed with tsutsugamushi disease showed polyuria during therapy with doxycycline. After injection of vasopressin, urine output was decreased and urine osmolarity was increased. So, we diagnosed as central diabetic insipidus. We report a case of central diabetes insipidus occurring during therapy for tsutsugamushi disease.
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