Korean J Obstet Gynecol.  2010 Sep;53(9):833-837. 10.5468/kjog.2010.53.9.833.

Transient newborn neutropenia immediately after chemotherapy during pregnancy: A case report

  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. jhs0927@snu.ac.kr


The incidence of acute leukemia in pregnancy is as low as 1 in 75,000 pregnancies. There is no established guideline for the treatment of leukemia during midtrimester pregnancy. But nowadays, consensus is not to delay the leukemia treatment with chemotherapy even in pregnancy. Many authors reported successful outcomes of mothers and newborns. Because of the leukemia itself and side effects of the chemotherapy, anemia, thrombocytopenia and neutropenia are commonly encountered in women treated with chemotherapy. With chemotherapy in utero just before the delivery, the newborn could be neutopenic. We report one case of midtrimester pregnant woman who took chemotherapy for leukemia and suffered from neutropenic fever and preterm labor. The newborn was neutropenic. However, both the mother and the baby were successfully recovered from neutropenia.


Pregnancy; Acute leukemia; Chemotherapy; Newborn; Neutropenia

MeSH Terms

Infant, Newborn
Obstetric Labor, Premature
Pregnancy Trimester, Second
Pregnant Women


  • Figure 1 Newborn absolute neutrophil count (ANC): newborn neutropenia after chemotherapy in utero was recovered with granulocyte colony stimulating factor.


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