Korean J Perinatol.  2013 Dec;24(4):310-314. 10.14734/kjp.2013.24.4.310.

A Case of Neonatal Isoimmune Hemolytic Disease due to Anti-Mi(a) Antibody with Massive Fetomaternal Hemorrhage

  • 1Department of Pediatrics, Kwangju Christian Hospital, Gwangju, Korea. youjuhee@daum.net


Authors experienced a newborn treated with severe anemia transferred to our hospital due to pulselessness and apnea shortly after birth. Laboratory analysis of the blood on admission revealed hemoglobin 3.1 g/dL, reticulocyte 11.0%. Kleihauer-Betke test for fetal hemoglobin from maternal blood was seen Hgb F 7%, then we suggested almost 180 ml fetomaternal hemorrhage. But, anemia was not improved despite repeated packed RBC transfusion. So, we evaluated the other cause of intractable anemia. The results were as follows; the Coombs' test was positive. The antibody identification test using mother's serum revealed anti-Mia antibody. The patient improved with supportive treatment, but got hypoxic brain injury due to massive fetomaternal hemorrhage. At day 29, the infant was doing well and was discharged. We report a case of neonatal isoimmune hemolytic disease due to anti-Mia with massive fetomaternal hemorrhage with a brief review of the related literatures.


Hemolytic disease of the newborn; Miltenberger; Anemia

MeSH Terms

Brain Injuries
Coombs Test
Fetal Hemoglobin
Fetomaternal Transfusion*
Infant, Newborn
Fetal Hemoglobin


  • Fig. 1 Chest radiograph showed a pneumothorax in the right lung at 1 day after birth.

  • Fig. 2 MRI scan of brain demonstrates diffuse low signal intensities on both fronto-parietotemporal lobes (Right


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