Korean J Blood Transfus.  1995 Dec;6(2):193-200.

Two Cases of Hemolytic Disease of the Newbom due to Anti-E Antibody in Sisters

• Kim SW
• Lee JH
• Park YW
• Sin BM

Abstract

Isoimmune hemolytic disease of the newborn due to anti-E is a disease characterized by the progressive neonatal hyperbilimbinemia and anemia which is caused by the IgG antibody transmitted from the mother to the ferns. Authors have experienced two cases of isoimmune hemolytic disease due to anti-E, who presented with jaundice on the first and the second day of life, respectively. The ABO and Rh blood types of their mother and father were B, CcDee and O, ccDEE, respectively. Both babies showed positive direct Coombs test and the mother showed strong positive indirect Coombs test. Antibody identification tests were made only in the first case and the mother, both of which revealed anti-E antibody. The first case was treated with phototherapy for 3 days and two blood transfusions. The second case was treated with phototherapy for 6 days and two exchange transfusions.

MeSH Terms

Anemia
Blood Transfusion
Coombs Test
Fathers
Ferns
Humans
Immunoglobulin G
Infant, Newborn
Jaundice
Mothers
Phototherapy
Siblings*
Immunoglobulin G