Korean J Physiol Pharmacol.  2003 Jun;7(3):181-185.

Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney

Affiliations
  • 1Department of Physiology, Chonnam National University Medical Schoo, Korea. julee@jnu.ac.kr
  • 2Department of Physiology, Seonam University College of Medicine, Korea.
  • 3Department of Pharmacology, Chosun University Medical College, Gwangju, Korea.

Abstract

Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the nervous and connective tissues passing along the renal artery and vein, and painting these vessels with 10% phenol solution through a midline abdominal incision. Three days later, the expression of AQP1-4 proteins in the denervated kidneys was determined. The content of norepinephrine was found significantly decreased following the denervation. Accordingly, the expression of AQP2 proteins was markedly decreased. The expression of AQP3 and AQP4 was also slightly but significantly decreased, while that of AQP1 was not. Neither the basal nor the AVP-stimulated accumulation of cAMP was significantly affected in the denervated kidney. It is suggested that the sympathetic nervous system has a tonic stimulatory effect on AQP channels in the kidney.

Keyword

Aquaporins; Sympathetic nervous system; Kidney

MeSH Terms

Animals
Aquaporin 2
Aquaporins*
Connective Tissue
Denervation
Humans
Kidney*
Male
Norepinephrine
Paint
Paintings
Phenol
Rats*
Rats, Sprague-Dawley
Renal Artery
Sympathetic Nervous System
Veins
Aquaporin 2
Aquaporins
Norepinephrine
Phenol
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