J Korean Acad Periodontol.  1997 Sep;27(3):597-602. 10.5051/jkape.1997.27.3.597.

Periodontal treatment of a Glanzmann's thrombasthenia patient: A case report

Affiliations
  • 1Department of Periodontology, School of Dentistry, Seoul National University, Korea.

Abstract

Glanzmann's thrombasthenia is a qualitative platelet disorder characterized by a deficiency in the platelet membrane glycoproteins IIb/IIIa. It belongs to a group of hereditary platelet disorders typified by normal platelet numbers and a prolonged bleeding time. The severity of bleeding does not correlate with the severity of the platelet glycoprotein IIb/IIIa abnormality. The present case report describes the periodontal treatment of a patient with Glanzmann's thrombasthenia. A 30-year-old female with a history of Glanzmann's thrombasthenia was referred for gingival bleeding on tooth brushing and discomforts in #38 area. The periodontal finding revealed a diagnosis of localized slight adult periodontitis. Root planing and extraction of #38 was performed under 12 pack of platelets transfusion and digital compression was done for hemostasis. The gingival bleeding ceased within a day in maxilla and 2 days later in mandible. 42 pack of platelets was administered for 3 days of post-treatment and for iron-deficiency anemia 3 pack of RBCs was transfused 2 days later. 1 week later the inflammation in gingiva disappeared and gingival stippling appeared. The clinical result we got was good and in such a medically compromised patient it is an ability to maintain a proper oral hygiene that is essential both for oral and systemic health.

Keyword

thrombasthenia; Glanzmann's; blood platelet disorder; glycoproteins

MeSH Terms

Adult
Anemia, Iron-Deficiency
Bleeding Time
Blood Platelet Disorders
Blood Platelets
Chronic Periodontitis
Diagnosis
Female
Gingiva
Glycoproteins
Hemorrhage
Hemostasis
Humans
Inflammation
Mandible
Maxilla
Oral Hygiene
Platelet Count
Platelet Membrane Glycoproteins
Root Planing
Thrombasthenia*
Tooth
Glycoproteins
Platelet Membrane Glycoproteins
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