Korean J Anesthesiol.  2009 Oct;57(4):507-510. 10.4097/kjae.2009.57.4.507.

Anesthetic experience for orthopedic surgery on a patient with Glanzmann's thrombasthenia refractory to platelet transfusion: A case report

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, National Health Insurance Corporation Ilsan Hospital, Ilsan, Korea.
  • 2Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. anekim@hallym.or.kr

Abstract

Glanzmann's thrombasthenia is an autosomal recessive bleeding disorder caused by qualitative or quantitative abnormalities of the platelet glycoprotein IIb/IIIa (GP IIb/IIIa), which can lead to excessive bleeding. Glanzmann thrombasthenia is associated with clinical variability, with some patients only having minimal bruising and others having frequent, severe and potentially fatal hemorrhages. Platelet transfusions, which used to be the standard treatment, may lead to the development of antibodies to HLA and/or GPIIb/IIIa, thereby rendering future transfusions ineffective. Glanzmann's thrombasthenia can be a severe hemorrhagic disease; however, the prognosis is excellent with careful supportive care. In this case, administering allogenic plateletpheresis to patients with Glanzmann's thrombasthenia who were refractory to platelet transfusions was found to be successful during bone surgeries.

Keyword

General anesthesia; Glanzmann's thrombasthenia; Platelet transfusion

MeSH Terms

Anesthesia, General
Antibodies
Blood Platelets
Glycoproteins
Hemorrhage
Humans
Orthopedics
Platelet Transfusion
Plateletpheresis
Prognosis
Thrombasthenia
Antibodies
Glycoproteins
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