J Korean Assoc Maxillofac Plast Reconstr Surg.  2010 Sep;32(5):396-405.

The Effect of ER:YAG Laser & ER,CR:YSGG Laser on the Tissue of the Inflammation-Induced Mouse

• Park TI
• Lee HS
• Lee HJ
• Chae CH
• Lee YJ
• Byeon KS
• Hong SM
• Choi MR
• Park JW

Abstract

PURPOSE
This study was performed to find out the effects of the Er:YAG laser (Key Laser) & Er,Cr:YSGG laser (Water Laser) on inflammatory tissues.
MATERIALS AND METHODS
It was performed on about 20 g, 6 weeks male ICR mouses. They were grouped into the control (negative), the inflammation induced 'control' (positive), Er,Cr:YSGG laser exposured group after inducing inflammation, Er:YAG lasere exposured group after inducing inflammation each 15 mouses. The mouses were applicated 0.5% DNFB 1 cc on ear skin twice a day for 4 days until symptom expression. After laser exposure, ear tissues were extracted and defined gene expression by RT-PCR. Then, tissue staining, lymphocytes observation, electromicroscophic laboratory were carried out.
RESULTS
Interleukin-1beta was expressed much less in the A-laser exposed group. Interleukin-1beta & Tumor Necrosis Factor-alpha were expressed 7 times lesser in the A-laser exposed group. The number of Lymphocytes related to inflammation was decreased rapidly in the A-laser exposed group in vivo. he number of cavity recovered normal was a little bigger in the A-laser exposed group after 5 days.
CONCLUSION
The expression of IL-1beta & TNF-alpha, hitologic change, observation with electron microscope shows that Erbium laser exposure causes lesser inflammation with A-laser rather than B-laser.

Keyword

Laser therapy; IL-1beta & TNF-alpha; Mice; Electron microscope

MeSH Terms

Animals
Dinitrofluorobenzene
Ear
Electrons
Erbium
Gene Expression
Humans
Inflammation
Interleukin-1beta
Laser Therapy
Lymphocytes
Male
Mice
Skin
Tumor Necrosis Factor-alpha
Dinitrofluorobenzene
Erbium
Interleukin-1beta
Tumor Necrosis Factor-alpha