Korean J Anat.
1999 Aug;32(4):535-541.
Carbonic anhydrase II immunostaining in the cerebellum of postnatal mice
- Affiliations
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- 1Department of Anatomy, Seoul National University College of Medicine, Korea.
- 2Department of Anatomy, College of Medicine, Hallym University, Korea.
Abstract
- The carbonic anhydrase II (CA-II) is specifically expressed in oligodendrocytes, the cells responsible for myelination in the central nervous system. However no direct evidence on relationship between myelin formation and CA-II immunoreactivity has been described. The aims of these studies are to investigate the relationship between CA-II and myelination during cerebellar development of mouse. Myelin staining was found on postnatal (P) 14, and its intensity increased in proportion to developmental age. CA-II positive oligodendrocytes were observed in the white matter of cerebellum on P 14 day. CA-II positive oligoden-drocytes also occured in the granular layer and Purkinje cell layers in the later stage of dvelopment. The parallel development in the CA-II expression and myelination during development suggests that CA-II in oligoendrocyte play a role to myelination.
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