Korean J Hematol.
1997 Nov;32(3):453-458.
A Case of AML Atypical M2 with Granulocytic Sarcoma in the Meninges Induced Remission by All-Trans Retinoic Acid and Combined Chemotherapy
- Affiliations
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- 1Department of Internal Medicine, Chonnam University Medical School, Kwangju, Korea.
- 2Department of Clinical Pathology, Chonnam University Medical School, Kwangju, Korea.
Abstract
- We repoarted a rare case of AML atypical M2 who developed granulocytic granulocyte sarcoma in the meninges which was induced complete remission with all-trans retinoic acid (ATRA), daunorubicin and cytosine arabinoside (Ara-C). Morphological and immunophenotypic study of leukemic cells in this patient suggested acute promyelocytic leukemia. However, leukemic clees lacked both t (15;17) and PML-RARalpha gene rearragement, rather showed t (8;21). The patient was diagnosed as AML atypical M2.
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