Korean J Lab Med.  2005 Apr;25(2):133-138.

Association of the CD14/-159 C->T Polymorphism with Variations in Serum Lipoproteins in Healthy Population

• Ha JS
• Ryoo NH
• Kim JR
• Jun DS

Abstract

BACKGROUND
The CD14 receptor is an important mediator for the activation of monocyte by lipo-polysaccharides. Recently described data indicate that the CD14/-159 C->T polymorphism is associated with elevated CD14 expression, decreased IgE and increased myocardial infarction risk. In the present study, we investigated the CD14/-159 C->T polymorphism to determine its association with lipid profile in healthy adults. METHODS: The CD14 promoter genotype was determined by polymerase chain reaction amplification-restriction fragment length polymorphism analysis in 156 healthy adults. Results of the CD14 promotor genotype were compared with total cholesterol, LDL, HDL, apo A1, apo B100, and triglyceride using one way ANOVA and independent T tests. RESULTS: The genotype frequencies were CC 13.5%, TT 35.9%, CT 50.6% and the T allele frequency was 61.2%; there was no association between CD14 promotor genotype and lipoprotein concentrations (P>0.05). CONCLUSIONS: Our results indicate that CD14/-159 C->T polymorphism is not associated with serum lipoprotein concentrations.

Keyword

CD14; Polymorphism; Lipoprotein

MeSH Terms

Adult
Apolipoprotein A-I
Cholesterol, LDL
Gene Frequency
Genotype
Humans
Immunoglobulin E
Lipoproteins*
Monocytes
Myocardial Infarction
Polymerase Chain Reaction
Triglycerides
Apolipoprotein A-I
Cholesterol, LDL
Immunoglobulin E
Lipoproteins