Korean J Clin Pathol.
1999 Oct;19(5):504-509.
The Total Antioxidant Capacity According to the Diet and the Life Style in Patients with the Chronic Cardiovascular Disease
- Affiliations
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- 1Department of Clinical Pathology, Kyungpook National University School of Medicine, Korea
- 2Department of Cardiology, Kyungpook National University School of Medicine, Korea
- 3Department of Food and Nutrition, Taegu University, Taegu, Korea
- 4Department of Food Science and Nutrition, Taegu Hyosung Catholic University, Taegu, Korea
Abstract
- BACKGROUND
Decreased antioxidant defense mechanisms and over-generated free radicals by either normal or aberrant metabolism play an important role in the pathogenesis of cardiovascular disease and cancer. And the life style and diet including antioxidant vitamin A and E have been thought an important factor in antioxidant systems. Recently, Total Antioxidant Status kit (TAS; Randox, UK) has been developed for measuring the total antioxidant capacity of blood. So we evaluated the association of life style and total antioxidant capacity in patients with chronic cardiovascular disease.
METHODS
Sixty six cases of chronic cardiovascular disease and sixty three normal controls were evaluated. Serum total antioxidant capacity was measured by Hitachi 747 (Hitachi Ltd, Japan) with TAS kit, vitamin A and E were measured by high performance liquid chromatography method, and serum lipid profile by Hitachi 7060 (Hitachi Ltd, Japan).
RESULTS
The mean total antioxidant capacity did not show difference between patients and controls. After 3 months, we detected significant increase of total antioxidant capacity, high-density lipoprotein cholesterol and mild increase of antioxidant vitamins and significant decrease of total cholesterol, triglyceride, lipoprotein (a). The heavy alcohol consumption group showed significant difference with other groups (P<0.05).
CONCLUSIONS
The measurement of total antioxidant capacity for the cardiovascular disease patients was thought to be useful to evaluate oxidative stress and antioxidant status. Alcohol consumption and supplementation with antioxidant vitamins could have an effect on total antioxidant capacity.
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