J Korean Neuropsychiatr Assoc.
2004 Sep;43(5):519-523.
Glutathione S-Transferase M1 Polymorphism and Schizophrenia
- Affiliations
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- 1Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea. knpsy@catholic.ac.kr
Abstract
OBJECTIVES
This study aimed to test the possible association between Glutathione S-Transferase M1 gene (GSTM1) variants and schizophrenia.
METHODS
One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method.
RESULTS
The GSTM1 null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interval=1.115-3.351), while GSTM1 genotype variants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores.
CONCLUSION
The present study suggests that the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population.
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