Korean J Physiol Pharmacol.  2012 Aug;16(4):231-236. 10.4196/kjpp.2012.16.4.231.

Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats

Affiliations
  • 1Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Korea.
  • 2Department of Neurology, School of Medicine, Kyungpook National University, Daegu 700-422, Korea.
  • 3Brain Science and Engineering Institute, Kyungpook National University, Daegu 700-422, Korea.
  • 4Department of Pharmacology, School of Medicine, Keimyung University, Daegu 700-712, Korea.
  • 5Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.

Abstract

We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake (W), slow-wave sleep (S) and paradoxical or rapid eye movement sleep (P), were scored every 10 sec by an experimenter. We measured mean episode duration and number of episode to determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not cause sleep disturbances and memantine may be a drug that causes severe sleep disturbance.

Keyword

Donepezil; Electroencephalography; Galantamine; Memantine; Sleep-wake state
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