J Korean Neurosurg Soc.  1996 Mar;25(3):519-525.

Effect of Taxol on the Function of Murine Microglial Cells

• Chae BM
• Kim JM

Abstract

The effect of taxol on the production of nitric oxide(NO) and reactive oxygen radicals(O2- and H2O2)and on the function of phagocytic activity of murine microglial cells were investigated. Stimulated cells also showed increased production such reactive oxygen radicals as surperoxide and hydrogen peroxide measured by luminometer after stimulated with phorbolmyristate acetate(PMA). Taxol alone had only being small effect on NO synthesis, whereas taxol in combination with rIFN-gamma synergistically increased NO synthesis in a dose dependent manner. The production of NO by taxol plus rIFN-gamma was reduced by such L-arginine analogues as N(G)-mono-metyl-L-arginine Monohydrate(N(G)MMA), and N-amino-L-arginine(NAA) and arginase which decomposes L-arginine. Collectively, the data illustrate the potential for taxol to activate microglia-mediated anticancer mechanisms in the brain in addition to its better characterized effects on ovarian, beast, and lung cancer.

MeSH Terms

Arginase
Arginine
Brain
Hydrogen Peroxide
Lung Neoplasms
Oxygen
Paclitaxel*
Reactive Oxygen Species
Arginase
Arginine
Hydrogen Peroxide
Oxygen
Paclitaxel
Reactive Oxygen Species