Genomics Inform.  2015 Jun;13(2):40-44. 10.5808/GI.2015.13.2.40.

Genetic Architecture of Transcription and Chromatin Regulation

• Kim K
• Bang H
• Lee K
• Choi JK

• KMID: 2009145
• DOI: http://doi.org/10.5808/GI.2015.13.2.40

Abstract

DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation.

Keyword

epigenetic process; gene expression; quantitative trait loci; regulatory regions

MeSH Terms

Chromatin*
Epigenesis, Genetic
Epigenomics
Gene Expression
Genetic Variation
Humans
Oligonucleotide Array Sequence Analysis
Quantitative Trait Loci
Regulatory Sequences, Nucleic Acid
Research Design
Transcription Factors
Yeasts
Chromatin
Transcription Factors