- Genetic and epigenetic alterations of colorectal cancer
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Hong SN
- KMID: 2417644
- Intest Res.
- 2018 Jul;16(3):327-337.
- doi: 10.5217/ir.2018.16.3.327
Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing... -
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- Can We Use Single Nucleotide Polymorphism and Runt Domain Transcription Factor 3 Methylation as Tumor Markers for Bladder Cancer?
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Kim WJ, Kim YJ
- KMID: 2311855
- Korean J Urol.
- 2009 Apr;50(4):311-319.
PURPOSE: Although many tumor markers have been evaluated in relation to bladder cancer, none of these biomarkers reported to date has shown sufficient sensitivity and specificity for the detection of... -
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- A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation
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Kwon MJ, Yun MJ, Kim MK
- KMID: 2329057
- Obstet Gynecol Sci.
- 2016 Jul;59(4):328-332.
- doi: 10.5468/ogs.2016.59.4.328
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare disease entity that arises from the mesonephric duct system. FATWO is different than other gynecological cancers in terms of... -
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- Genetic Architecture of Transcription and Chromatin Regulation
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Kim K, Bang H, Lee K, Choi JK
- KMID: 2009145
- Genomics Inform.
- 2015 Jun;13(2):40-44.
- doi: 10.5808/GI.2015.13.2.40
DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic... -
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- Genetic controls of Th17 cell differentiation and plasticity
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Dong C
- KMID: 991617
- Exp Mol Med.
- 2011 Jan;43(1):1-6.
- doi: 10.3858/emm.2011.43.1.007
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2... -
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- Genetic and Epigenetic Marker-Based DNA Test of Stool Is a Promising Approach for Colorectal Cancer Screening
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An SW, Kim NK, Chung HC
- KMID: 1758558
- Yonsei Med J.
- 2009 Jun;50(3):331-334.
- doi: 10.3349/ymj.2009.50.3.331
Colorectal cancer (CRC) is one of the most common malignancies and leading cause of cancer-related deaths in the world. However, it may be treated effectively by surgical removal of the... -
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- Clinically relevant genetic characterization of prostate tumors: How close are we to the goal?
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Tolkach Y, Imkamp F, Godin K, Van Poppel H
- KMID: 2133272
- Korean J Urol.
- 2015 Feb;56(2):90-98.
- doi: 10.4111/kju.2015.56.2.90
Substantial efforts are being made in research on the molecular genetic characterization of prostate cancer. The number of fundamental research programs in prostate cancer molecular biology and genetics is overwhelming.... -
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- Expression of Multidrug Resistance Protein 1 in Human Hepatocellular Carcinoma
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Kang YK
- KMID: 1443734
- Korean J Pathol.
- 2011 Jun;45(3):281-289.
- doi: 10.4132/KoreanJPathol.2011.45.3.281
BACKGROUND: Multidrug resistance protein 1 (MDR1) encoded by ATP-binding cassette, sub-family B (Mdr/Tap), member 1 (ABCB1) mediates cross-resistance to antineoplastic drugs, and its expression is related to tumor aggressiveness. METHODS: MDR1... -
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- The Ratio of 2nd to 4th Digit Length in Korean Alcohol-dependent Patients
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Han C, Bae H, Lee YS, Won SD, Kim DJ
- KMID: 2170982
- Clin Psychopharmacol Neurosci.
- 2016 May;14(2):148-152.
- doi: 10.9758/cpn.2016.14.2.148
OBJECTIVE: The ratio of 2nd to 4th digit length (2D:4D) is a sexually dimorphic trait. Men have a relatively shorter second digit than fourth digit. This ratio is thought to... -
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- Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes
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Lee CG, Sahoo A, Im SH
- KMID: 1758557
- Yonsei Med J.
- 2009 Jun;50(3):322-330.
- doi: 10.3349/ymj.2009.50.3.322
The developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic mechanisms. The principal events, signaling pathways and the lineage determining factors... -
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- Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways
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Marschalek R
- KMID: 2373507
- Ann Lab Med.
- 2016 Mar;36(2):85-100.
- doi: 10.3343/alm.2016.36.2.85
Chromosomal translocations of the human mixed-lineage leukemia (MLL) gene have been analyzed for more than 20 yr at the molecular level. So far, we have collected about 80 direct MLL... -
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- Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects
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Lee JU, Kim JD, Park CS
- KMID: 2366325
- Yonsei Med J.
- 2015 Jul;56(4):877-886.
- doi: 10.3349/ymj.2015.56.4.877
Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches... -
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- Update on Early Nutrition and Food Allergy in Children
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Lee SE, Kim H
- KMID: 2374070
- Yonsei Med J.
- 2016 May;57(3):542-548.
- doi: 10.3349/ymj.2016.57.3.542
With growing evidence of an increase in the prevalence, food allergy has been emerged as a new public health problem. As treatment and management of food allergy remain challenging, more... -
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- Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
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Kondo Y
- KMID: 1758603
- Yonsei Med J.
- 2009 Aug;50(4):455-463.
- doi: 10.3349/ymj.2009.50.4.455
DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in... -
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- Barrett's Esophagus and Cancer Risk: How Research Advances Can Impact Clinical Practice
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di Pietro , Alzoubaidi D, Fitzgerald RC
- KMID: 1792358
- Gut Liver.
- 2014 Jul;8(4):356-370.
Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer... -
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- Can we use methylation markers as diagnostic and prognostic indicators for bladder cancer?
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Kim YJ, Kim WJ
- KMID: 2426519
- Investig Clin Urol.
- 2016 Jun;57(Suppl 1):S77-S88.
- doi: 10.4111/icu.2016.57.S1.S77
Urothelial carcinomas of the urinary bladder have diverse biological and functional characteristics, and numerous factors are likely to be involved in recurrence, progression, and patient survival. While several molecular markers... -
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- Artificial gametes from stem cells
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Moreno I, Miguez-Forjan JM, Simon C
- KMID: 1879362
- Clin Exp Reprod Med.
- 2015 Jun;42(2):33-44.
- doi: 10.5653/cerm.2015.42.2.33
The generation of artificial gametes is a real challenge for the scientific community today. In vitro development of human eggs and sperm will pave the way for the understanding of... -
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- Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension
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Kim JD, Lee A, Choi J, Park Y, Kang H, Chang W, Lee MS, Kim J
- KMID: 2155429
- Exp Mol Med.
- 2015 Jul;47(7):e175.
- doi: 10.1038/emm.2015.45
Pulmonary arterial hypertension (PAH) is a rare but progressive and currently incurable disease, which is characterized by vascular remodeling in association with muscularization of the arterioles, medial thickening and plexiform... -
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- EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
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Zhou W, Jiang Z, Li X, Xu F, Liu Y, Wen P, Kong L, Hou M, Yu J
- KMID: 1794413
- J Korean Med Sci.
- 2009 Feb;24(1):97-103.
- doi: 10.3346/jkms.2009.24.1.97
Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still... -
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- Epigenetic regulation and chromatin remodeling in learning and memory
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Kim S, Kaang BK
- KMID: 2367527
- Exp Mol Med.
- 2017 Jan;49(1):e281.
- doi: 10.1038/emm.2016.140
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the... -
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